Head and neck cancer pertinent cancer susceptibilityGene: FANCB
Comment on mode of inheritance: Changed to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males).- the gene is encoded on chromosome Xp22.2
Created: 25 Sep 2017, 1:24 p.m.
Comment on publications: added publication to support change in MOI
Created: 25 Sep 2017, 11:59 a.m.
Comment on list classification: Details checked against the original gene list from Clare Turnbull.
Created: 26 Jul 2017, 11:18 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Head and neck cancer
Ellen McDonagh: Comment on list classification
Mode of inheritance for FANCB was changed to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Publications for FANCB were set to 21910217
This gene has been classified as Green List (High Evidence).
FANCB was added to Head and neck cancerpanel. Sources: Expert list
FANCB was created by ellenmcdonagh