Multiple bowel polyps

Gene: MUTYH

Green List (high evidence)

MUTYH (mutY DNA glycosylase)
EnsemblGeneIds (GRCh38): ENSG00000132781
EnsemblGeneIds (GRCh37): ENSG00000132781
OMIM: 604933, Gene2Phenotype
MUTYH is in 12 panels

1 review

Ian Frayling (Cardiff University)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • UKGTN
  • Emory Genetics Laboratory
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • MYH-Associated Polyposis
  • MUTYH-Associated Polyposis
  • Familial Adenomatous Polyposis, 2
  • adenomatous polyposis
OMIM
604933
Clinvar variants
Variants in MUTYH
Penetrance
Complete
Panels with this gene

History Filter Activity

29 Jan 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

28 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MUTYH was set to BIALLELIC, autosomal or pseudoautosomal

28 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

MUTYH was added to Multiple bowel polypspanel. Source: Eligibility statement prior genetic testing

28 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MUTYH was set to BIALLELIC, autosomal or pseudoautosomal

28 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

MUTYH was added to Multiple bowel polypspanel. Source: UKGTN

28 Aug 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MUTYH was set to BIALLELIC, autosomal or pseudoautosomal

28 Aug 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

MUTYH was added to Multiple bowel polypspanel. Source: Emory Genetics Laboratory

28 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MUTYH was added to Multiple bowel polypspanel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Eligibility statement prior genetic testing