Inherited non-medullary thyroid cancerGene: DIRAS3
Comment when marking as ready: Imprinted DIRAS3 (ARHI) allele is silenced (first hit) during normal development, the remaining expressed allele is open to somatic genetic (large deletion) or epigenetic events (second hit), early in neoplasia as is likely the case in follicular carcinogenesis (PMID: 15546898)
Created: 31 Jul 2017, 12:19 p.m.
Not aware of evidence linking germline alterations of DIRAS3 to FNMTC
Created: 13 Jun 2017, 1:55 p.m.
No evidence of clinical association
Created: 9 Jun 2017, 9:08 a.m.
All genes have been reviewed and the reviews evaluated. 07.08.2017
This gene has been classified as Red List (Low Evidence).
DIRAS3 was created by sleigh
DIRAS3 was added to Inherited non-medullary thyroid cancerpanel. Sources: Literature