Inherited non-medullary thyroid cancer

Gene: FOXE1

Amber List (moderate evidence)

FOXE1 (forkhead box E1)
EnsemblGeneIds (GRCh38): ENSG00000178919
EnsemblGeneIds (GRCh37): ENSG00000178919
OMIM: 602617, Gene2Phenotype
FOXE1 is in 9 panels

3 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least one variant reported in two apparently unrelated cases, supportive animal cell line data also available (PMID: 25381600)
Created: 31 Jul 2017, 12:34 p.m.
Comment on phenotypes: Biallelic variants associated with Bamforth-Lazarus syndrome 241850
Created: 31 Jul 2017, 12:30 p.m.

Emma Woodward (Manchester Centre for Genomic Medicine)

Red List (low evidence)

SNP 60kb from FOXE1 has shown association with NMTC in GWAS studies but no causative role of FOXE1 been demonstrated as yet.
Created: 13 Jun 2017, 2:06 p.m.
SNP 60kb from FOXE1 has shown association with NMTC in GWAS studies but no causative role of FOXE1 been demonstrated as yet.
Created: 13 Jun 2017, 2:06 p.m.

Fiona Lalloo (Manchester Centre for Genomic Medicine)

Red List (low evidence)

GWAS suggest some association but not clear. No clinical utility
Created: 9 Jun 2017, 9:10 a.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Thyroid cancer, nonmedullary, 4} 616534
OMIM
602617
Clinvar variants
Variants in FOXE1
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

7 Aug 2017, Gel status: 2

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

All genes have been reviewed and the reviews evaluated. 07.08.2017

31 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

31 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

31 Jul 2017, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for FOXE1 were set to {Thyroid cancer, nonmedullary, 4} 616534

18 May 2017, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

FOXE1 was created by sleigh

18 May 2017, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

FOXE1 was added to Inherited non-medullary thyroid cancerpanel. Sources: Radboud University Medical Center, Nijmegen