Inherited non-medullary thyroid cancer

Gene: TG

Red List (low evidence)

TG (thyroglobulin)
EnsemblGeneIds (GRCh38): ENSG00000042832
EnsemblGeneIds (GRCh37): ENSG00000042832
OMIM: 188450, Gene2Phenotype
TG is in 4 panels

3 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least one biallelic variant reported in two siblings with recurrent goiters and metastatic follicular thyroid carcinoma in one of these. Parents were monozygous.
Created: 10 Jul 2017, 10:41 a.m.

Emma Woodward (Manchester Centre for Genomic Medicine)

Red List (low evidence)

I am not aware of any publications demonstrating the presence of germline thyroglobulin mutations in FNMTC. Couple of SNPs have shown association,
Akdi A, Pérez G, Pastor S, Castell J, Biarnés J, Marcos R, Velázquez A.
Thyroid. 2011 May;21(5):519-25. doi: 10.1089/thy.2010.0384. Epub 2011 Apr 10.
PMID: 21476894

He H, Nagy R, Liyanarachchi S, Jiao H, Li W, Suster S, Kere J, de la Chapelle A.
Cancer Res. 2009 Jan 15;69(2):625-31.


Here, we don't know if the balletic changes were independently responsible for development of ca thyroid, so I wouldn't include.
Raef H, Al-Rijjal R, Al-Shehri S, Zou M, Al-Mana H, Baitei EY, Parhar RS, Al-Mohanna FA, Shi Y.
J Clin Endocrinol Metab. 2010 Mar;95(3):1000-6. doi: 10.1210/jc.2009-1823. Epub 2010 Jan 20.
PMID: 20089614

Created: 13 Jun 2017, 6:24 a.m.

Fiona Lalloo (Manchester Centre for Genomic Medicine)

Red List (low evidence)

Single case described.
Created: 9 Jun 2017, 8:16 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • UKGTN
  • Radboud University Medical Center, Nijmegen
  • Literature
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Thyroid dyshormonogenesis 3 274700
OMIM
188450
Clinvar variants
Variants in TG
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

7 Aug 2017, Gel status: 1

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

All genes have been reviewed and the reviews evaluated. 07.08.2017

10 Jul 2017, Gel status: 1

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

10 Jul 2017, Gel status: 1

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

10 Jul 2017, Gel status: 3

Set publications

Sarah Leigh (Genomics England Curator)

Publications for TG were set to 16403815; 21476894; 28345837

18 May 2017, Gel status: 3

Added New Source

Sarah Leigh (Genomics England Curator)

TG was added to Inherited non-medullary thyroid cancerpanel. Source: UKGTN

18 May 2017, Gel status: 2

Added New Source

Sarah Leigh (Genomics England Curator)

TG was added to Inherited non-medullary thyroid cancerpanel. Source: Radboud University Medical Center, Nijmegen

18 May 2017, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

TG was added to Inherited non-medullary thyroid cancerpanel. Source: Literature

18 May 2017, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

TG was created by sleigh

18 May 2017, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

TG was added to Inherited non-medullary thyroid cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services