Inherited non-medullary thyroid cancer

Gene: WRN

Green List (high evidence)

WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels

3 reviews

Emma Woodward (Manchester Centre for Genomic Medicine)

Green List (high evidence)

Can be included, although other phenotypic features of Werner would be apparent as their penetrance is much higher than for NTMC in Werner.
Created: 13 Jun 2017, 6:30 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Fiona Lalloo (Manchester Centre for Genomic Medicine)

Green List (high evidence)

Should pick up this diagnosis clinically. Is clear evidence of association with thyroid malignancy
Created: 9 Jun 2017, 8:26 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner Syndrome

Publications

Variants in this GENE are reported as part of current diagnostic practice

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Thyroid cancers have been associated with Werner syndrome 277700. WRN associated with Werner syndrome 277700 in OMIM and as a confirmed G2P. At least 10 variants reported.
Created: 10 Jul 2017, 12:57 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner syndrome 277700

Publications

History Filter Activity

7 Aug 2017, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

All genes have been reviewed and the reviews evaluated. 07.08.2017

10 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 Jul 2017, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for WRN were set to 8722214; 23573208; 8602509

18 May 2017, Gel status: 4

Added New Source

Sarah Leigh (Genomics England Curator)

WRN was added to Inherited non-medullary thyroid cancerpanel. Sources: UKGTN,Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Literature

18 May 2017, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

WRN was created by sleigh