Complex Parkinsonism (includes pallido-pyramidal syndromes)

Gene: GNAL

Amber List (moderate evidence)

GNAL (G protein subunit alpha L)
EnsemblGeneIds (GRCh38): ENSG00000141404
EnsemblGeneIds (GRCh37): ENSG00000141404
OMIM: 139312, Gene2Phenotype
GNAL is in 7 panels

2 reviews

alisdair mcneill (Sheffield childrens hospital)

Red List (low evidence)

reported to cause dystonia, not complex parkinsonism
Created: 29 Jun 2016, 7:16 p.m.




Ellen McDonagh (Genomics England Curator)

Comment on list classification: Is on the Complex Parkinson's Disease/Dystonia NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual. Huw Morris (UCL) suggested that this gene be demoted to amber on the dystonia gene panel due to some uncertainty regarding the prevelance and the pathogenicity of variants - see PMID: 25111208 which is a comment on PMID: 24535567, and the author's reply PMID: 25111209. Since then (2014) multiple studies have been published - see PMIDs provided under publications below.
Created: 10 Jun 2016, 11:11 a.m.


Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
  • Expert Review Amber
  • Expert list
  • Dystonia 25, 615073
Clinvar variants
Variants in GNAL
Panels with this gene

History Filter Activity

10 Jun 2016, Gel status: 2

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for GNAL were set to; 27222887; 27123488; 27093447; 26810727; 26725140; 26506956; 26365774; 25847575; 25382112

10 Jun 2016, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

10 Jun 2016, Gel status: 0


Ellen McDonagh (Genomics England Curator)

GNAL was created by ellenmcdonagh

10 Jun 2016, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

GNAL was added to Complex Parkinsonism (includes pallido-pyramidal syndromes)panel. Sources: Expert list