Familial hidradenitis suppurativaGene: TNF
Comment on list classification: Kept rating as red based on expert review, and insufficient evidence for disease causation.
Created: 6 Jul 2017, 2:17 p.m.
SNP analysis in PMID:23106544 reports that TNF gene polymorphism in the promoter regions (-238) was associated with a predisposition to hidradenitis suppurativa (HS). Added 'promoter' tag to highlight this information.
Created: 19 Jun 2017, 10:34 a.m.
Mode of inheritance
predisposition to hidradenitis suppurativa
6th July 2017: Revised panel and promoted to Version 1.0 based on expert review. Although PSENEN, NCSTN and PSEN1 (all green genes on this panel) collectively only account for approximately 7% of all hidradenitis suppurativa (HS), there is insufficient evidence to promote any further genes to green at this time.
This gene has been classified as Red List (Low Evidence).
TNF was created by rfoulger
TNF was added to Familial hidradenitis suppurativapanel. Sources: Literature