GI tract tumours

Gene: CDH1

Amber List (moderate evidence)

CDH1 (cadherin 1)
EnsemblGeneIds (GRCh38): ENSG00000039068
EnsemblGeneIds (GRCh37): ENSG00000039068
OMIM: 192090, Gene2Phenotype
CDH1 is in 9 panels

3 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 31 Jul 2019, 12:28 p.m. | Last Modified: 31 Jul 2019, 12:28 p.m.
Panel Version: 1.13

Ellen Thomas (Genomics England Curator)

Comment on list classification: Discussed with CT - penetrance not high enough for clinical utility at this time.
Created: 10 May 2016, 8:20 p.m.

Ian Frayling (Cardiff University)

Green List (high evidence)

Good evidence that CDH1 predisposes modestly to rectum (and possibly) colon cancer
Created: 8 Dec 2015, 2:14 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

History Filter Activity

12 May 2017, Gel status: 2

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

11 May 2017, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

11 May 2017, Gel status: 0


Ellen McDonagh (Genomics England Curator)

CDH1 was created by ellenmcdonagh

11 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

CDH1 was added to GI tractpanel. Sources: Emory Genetics Laboratory,Expert Review Red