GI tract tumours

Gene: MSH3

Red List (low evidence)

MSH3 (mutS homolog 3)
EnsemblGeneIds (GRCh38): ENSG00000113318
EnsemblGeneIds (GRCh37): ENSG00000113318
OMIM: 600887, Gene2Phenotype
MSH3 is in 2 panels

2 reviews

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)


Treena Cranston (Oxford)

Red List (low evidence)

Discussed with Prof Ian Tomlinson. To be added to PanelApp as there has been a recent proposal that it may be asssociated with autosomal recessive polyposis/CRC. Not yet published hence low evidence.
Created: 20 Jul 2016, 7:09 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal


Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • Research
  • Expert Review Red
Clinvar variants
Variants in MSH3
Panels with this gene

History Filter Activity

29 Jan 2019, Gel status: 1

Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to MSH3.

12 May 2017, Gel status: 1

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

11 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH3 was added to GI tractpanel. Sources: Research,Expert Review Red

11 May 2017, Gel status: 0


Ellen McDonagh (Genomics England Curator)

MSH3 was created by ellenmcdonagh