Familial cicatricial alopeciaGene: HLA-DRA
This has been associated with a form of scarring alopecia in one Indian family but with no fine mapping of the locus. Amber because of the single family reports and only component features of other syndromes.
Created: 22 Jun 2017, 2:59 p.m.
Comment on list classification: Updated rating from Red to Amber to match expert review.
Created: 13 Jul 2017, 1:30 p.m.
Orphanet used as source for HLA-DRA and Graham Little syndrome- a subtype of lichen planopilaris characterized by symptoms including progressive cicatricial (scarring) alopecia.
Created: 22 Nov 2016, 5:12 p.m.
20 July 2017: Reviews from Prof. John McGrath were assessed, and panel was revised largely to reflect his expert review. Demoted FOXN1 and GJA1 to grey because the congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel. For most of the red genes, there is only very minor (often indirect) evidence to support a link to cicatricial alopecia, but they remain on the panel, for now, for completeness.
This gene has been classified as Amber List (Moderate Evidence).
HLA-DRA was created by rfoulger
HLA-DRA was added to Familial cicatricial alopeciapanel. Sources: Other