Comment on list classification: Rated Amber as additional cases required to validate the causal association with the phenotype.
Currently not associated with any phenotype in OMIM but a probable gene for Atypical Noonan Syndrome in G2P.
Created: 5 Aug 2020, 12:27 p.m. | Last Modified: 5 Aug 2020, 12:27 p.m.
Panel Version: 1.61
Two individuals reported. One de novo variant, the inheritance of the other variant uncertain. Some supportive functional data. Rated as LIMITED by ClinGen.
Sources: Expert list
Created: 3 Jul 2020, 10:11 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Gene: rras has been classified as Amber List (Moderate Evidence).
gene: RRAS was added gene: RRAS was added to RASopathies. Sources: Expert list Mode of inheritance for gene: RRAS was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: RRAS were set to 24705357 Phenotypes for gene: RRAS were set to Noonan syndrome Review for gene: RRAS was set to AMBER