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Parathyroid Cancer

Gene: CDC73

Green List (high evidence)

CDC73 (cell division cycle 73)
EnsemblGeneIds (GRCh38): ENSG00000134371
EnsemblGeneIds (GRCh37): ENSG00000134371
OMIM: 607393, Gene2Phenotype
CDC73 is in 8 panels

2 reviews

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Expert list
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Hyperparathyroidism, familial primary, 145000
  • Hyperparathyroidism-jaw tumor syndrome, 145001
  • Parathyroid adenoma with cystic changes, 145001
  • Parathyroid carcinoma, 608266
  • Parathyroid Carcinoma
  • Pituitary Cancer, Parathyroid and Hypercalcemia
  • Parathyroid Cancer
OMIM
607393
Clinvar variants
Variants in CDC73
Penetrance
Complete
Panels with this gene

History Filter Activity

14 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

14 Feb 2016, Gel status: 3

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for CDC73 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

18 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

CDC73 was added to Parathyroid Cancerpanel. Source: Eligibility statement prior genetic testing

18 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene CDC73 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

18 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

CDC73 was added to Parathyroid Cancerpanel. Source: Expert list

18 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene CDC73 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

18 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

CDC73 was added to Parathyroid Cancerpanel. Source: UKGTN

18 Aug 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene CDC73 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

18 Aug 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

CDC73 was added to Parathyroid Cancerpanel. Source: Illumina TruGenome Clinical Sequencing Services

18 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

CDC73 was added to Parathyroid Cancerpanel. Sources: Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,UKGTN,Expert list