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Infantile enterocolitis & monogenic inflammatory bowel disease v1.19 G6PC3 Sarah Leigh Phenotypes for gene: G6PC3 were changed from Congenital neutropenia to Dursun syndrome OMIM:612541; Neutropenia, severe congenital 4, autosomal recessive OMIM:612541; autosomal recessive severe congenital neutropenia due to G6PC3 deficiency MONDO:0012930
Infantile enterocolitis & monogenic inflammatory bowel disease v1.18 ANO1 Arina Puzriakova Classified gene: ANO1 as Amber List (moderate evidence)
Infantile enterocolitis & monogenic inflammatory bowel disease v1.18 ANO1 Arina Puzriakova Added comment: Comment on list classification: Rating Amber, awaiting further cases and review of phenotype associated with variants in this gene.
Infantile enterocolitis & monogenic inflammatory bowel disease v1.18 ANO1 Arina Puzriakova Gene: ano1 has been classified as Amber List (Moderate Evidence).
Infantile enterocolitis & monogenic inflammatory bowel disease v1.17 ANO1 Arina Puzriakova gene: ANO1 was added
gene: ANO1 was added to Infantile enterocolitis & monogenic inflammatory bowel disease. Sources: Literature
Mode of inheritance for gene: ANO1 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: ANO1 were set to 32487539
Phenotypes for gene: ANO1 were set to Impaired intestinal peristalsis; Haemorrhagic diarrhoea; Dysmorphic features
Review for gene: ANO1 was set to AMBER
Added comment: PMID: 32487539 (2020) - Two affected sibs presenting in early infancy with impaired intestinal peristalsis, intestinal pneumatosis and dysmorphic features. Delayed motor and language development was reported in one sibling, however, the other sibling died at 5 months from cardiac arrest and therefore a psychomotor assessment was not performed. Exome sequencing identified a homozygous truncating variant (c.897+3_897+6delAAGT, p.L300Vfs*58) in ANO1 which segregated with disease in the family. Functional data revealed that the variant led to lack of expression of functional TMEM16A in patient cells, which in turn abolished calcium-activated Cl- currents. Also supportive mouse model.
Sources: Literature
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 TRIM22 Zornitza Stark gene: TRIM22 was added
gene: TRIM22 was added to Infantile enterocolitis & monogenic inflammatory bowel disease. Sources: Expert list
Mode of inheritance for gene: TRIM22 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: TRIM22 were set to 26836588
Phenotypes for gene: TRIM22 were set to Inflammatory bowel disease
Review for gene: TRIM22 was set to GREEN
gene: TRIM22 was marked as current diagnostic
Added comment: Three unrelated families reported with bi-allelic variants in this gene, and very early onset IBD, some functional data.
Sources: Expert list
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 RIPK1 Zornitza Stark gene: RIPK1 was added
gene: RIPK1 was added to Infantile enterocolitis & monogenic inflammatory bowel disease. Sources: Expert list
Mode of inheritance for gene: RIPK1 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: RIPK1 were set to 30026316; 30591564; 31213653
Phenotypes for gene: RIPK1 were set to Immunodeficiency 57, MIM#618108
Review for gene: RIPK1 was set to GREEN
Added comment: Ten families reported, inflammatory bowel disease/enteropathy is a common feature of this immune dysregulation syndrome.
Sources: Expert list
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 NOD2 Zornitza Stark gene: NOD2 was added
gene: NOD2 was added to Infantile enterocolitis & monogenic inflammatory bowel disease. Sources: Expert list
Mode of inheritance for gene: NOD2 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Publications for gene: NOD2 were set to 11385576; 17804789; 32463623
Phenotypes for gene: NOD2 were set to {Inflammatory bowel disease 1, Crohn disease} 266600; {Yao syndrome} 617321
Review for gene: NOD2 was set to GREEN
gene: NOD2 was marked as current diagnostic
Added comment: Variants in NOD2 (particularly bi-allelic ones) are associated with increased risk of Crohn's disease. 7% of a cohort of 401 patients with Crohn's had NOD2 bi-allelic variants.
Sources: Expert list
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 FERMT1 Zornitza Stark reviewed gene: FERMT1: Rating: RED; Mode of pathogenicity: None; Publications: 19057668, 27537055, 32463623; Phenotypes: Kindler syndrome, MIM# 173650; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 BACH2 Zornitza Stark gene: BACH2 was added
gene: BACH2 was added to Infantile enterocolitis & monogenic inflammatory bowel disease. Sources: Expert list
Mode of inheritance for gene: BACH2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: BACH2 were set to 28530713
Phenotypes for gene: BACH2 were set to Immunodeficiency 60, MIM# 618394; inflammatory bowel disease; recurrent sinopulmonary infections
Review for gene: BACH2 was set to GREEN
Added comment: Two families and a mouse model.
Sources: Expert list
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 PTEN Zornitza Stark changed review comment from: GI polyps and diverticula are a feature of Cowden syndrome. The link between variants in PTEN and monogenic IBD appears based largely on experimental/mouse model evidence. There is a series of 34 individuals with PTEN variants and a range of autoimmune phenotypes reported in 22266152, including colitis. Considering PTEN-related conditions are relatively common as are auto-immune disorders, I am not convinced this is enough for causality.; to: GI polyps and diverticula are a feature of Cowden syndrome. The link between variants in PTEN and monogenic IBD appears based largely on experimental/mouse model evidence. There is a series of 34 individuals with PTEN variants and a range of autoimmune phenotypes reported in 22266152, including colitis. Considering PTEN-related conditions are relatively common as are auto-immune disorders, I am not convinced this is enough for causality. I also note this gene is Amber on the PID panel.
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 PTEN Zornitza Stark reviewed gene: PTEN: Rating: AMBER; Mode of pathogenicity: None; Publications: 23962154, 24882466, 25352295, 22266152; Phenotypes: Colitis; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 COL7A1 Zornitza Stark reviewed gene: COL7A1: Rating: RED; Mode of pathogenicity: None; Publications: 27537055, 25058236; Phenotypes: Epidermolysis bullosa dystrophica, AR, MIM# 226600; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Infantile enterocolitis & monogenic inflammatory bowel disease v1.16 ADAM17 Zornitza Stark reviewed gene: ADAM17: Rating: GREEN; Mode of pathogenicity: None; Publications: 22010916, 25804906, 21041656, 22236242; Phenotypes: Inflammatory neonatal-onset skin and bowel disease, MIM#614328; Mode of inheritance: None
Infantile enterocolitis & monogenic inflammatory bowel disease WAS Ellen McDonagh commented on WAS
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RG Ellen McDonagh commented on IL2RG
Infantile enterocolitis & monogenic inflammatory bowel disease CYBB Ellen McDonagh commented on CYBB
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Ellen McDonagh edited their review of ADA
Infantile enterocolitis & monogenic inflammatory bowel disease OTULIN Louise Daugherty classified OTULIN as green
Infantile enterocolitis & monogenic inflammatory bowel disease OTULIN Louise Daugherty commented on OTULIN
Infantile enterocolitis & monogenic inflammatory bowel disease OTULIN Owen Siggs added OTULIN to panel
Infantile enterocolitis & monogenic inflammatory bowel disease OTULIN Owen Siggs reviewed OTULIN
Infantile enterocolitis & monogenic inflammatory bowel disease CTLA4 Owen Siggs reviewed CTLA4
Infantile enterocolitis & monogenic inflammatory bowel disease SAMD9 Helen Brittain marked SAMD9 as ready
Infantile enterocolitis & monogenic inflammatory bowel disease SAMD9 Helen Brittain classified SAMD9 as green
Infantile enterocolitis & monogenic inflammatory bowel disease SAMD9 Helen Brittain added SAMD9 to panel
Infantile enterocolitis & monogenic inflammatory bowel disease SAMD9 Helen Brittain reviewed SAMD9
Infantile enterocolitis & monogenic inflammatory bowel disease HPS4 Ellen McDonagh commented on HPS4
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Sarah Leigh commented on STAT1
Infantile enterocolitis & monogenic inflammatory bowel disease Ellen McDonagh promoted panel to version 1
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Ellen McDonagh marked TGFBR2 as ready
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Ellen McDonagh classified TGFBR2 as green
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Ellen McDonagh marked TGFBR1 as ready
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Ellen McDonagh classified TGFBR1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Richard Scott classified TGFBR2 as red
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Richard Scott commented on TGFBR2
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Richard Scott classified TGFBR1 as red
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Richard Scott commented on TGFBR1
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Richard Scott classified STAT1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Richard Scott commented on STAT1
Infantile enterocolitis & monogenic inflammatory bowel disease RTEL1 Richard Scott classified RTEL1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease RTEL1 Richard Scott commented on RTEL1
Infantile enterocolitis & monogenic inflammatory bowel disease RAG1 Richard Scott classified RAG1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease RAG1 Richard Scott commented on RAG1
Infantile enterocolitis & monogenic inflammatory bowel disease G6PC3 Richard Scott classified G6PC3 as green
Infantile enterocolitis & monogenic inflammatory bowel disease G6PC3 Richard Scott commented on G6PC3
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Ellen McDonagh classified NCF4 as red
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Ellen McDonagh classified NCF4 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Ellen McDonagh commented on NCF4
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Ellen McDonagh classified NCF4 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Ellen McDonagh classified TGFBR2 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Ellen McDonagh commented on TGFBR2
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Ellen McDonagh commented on TGFBR1
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Ellen McDonagh classified TGFBR1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease STAT3 Ellen McDonagh marked STAT3 as ready
Infantile enterocolitis & monogenic inflammatory bowel disease STAT3 Ellen McDonagh classified STAT3 as green
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Ellen McDonagh classified STAT1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Ellen McDonagh commented on STAT1
Infantile enterocolitis & monogenic inflammatory bowel disease RTEL1 Ellen McDonagh classified RTEL1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease RTEL1 Ellen McDonagh commented on RTEL1
Infantile enterocolitis & monogenic inflammatory bowel disease RIPK2 Ellen McDonagh classified RIPK2 as red
Infantile enterocolitis & monogenic inflammatory bowel disease RIPK2 Ellen McDonagh commented on RIPK2
Infantile enterocolitis & monogenic inflammatory bowel disease RAG1 Ellen McDonagh classified RAG1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease RAG1 Ellen McDonagh commented on RAG1
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3R1 Ellen McDonagh classified PIK3R1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3R1 Ellen McDonagh commented on PIK3R1
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Ellen McDonagh marked PIK3CD as ready
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Ellen McDonagh classified PIK3CD as green
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Ellen McDonagh commented on PIK3CD
Infantile enterocolitis & monogenic inflammatory bowel disease NPC1 Ellen McDonagh classified NPC1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease NPC1 Ellen McDonagh commented on NPC1
Infantile enterocolitis & monogenic inflammatory bowel disease MASP2 Ellen McDonagh classified MASP2 as red
Infantile enterocolitis & monogenic inflammatory bowel disease MASP2 Ellen McDonagh classified MASP2 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease MASP2 Ellen McDonagh commented on MASP2
Infantile enterocolitis & monogenic inflammatory bowel disease IL21 Ellen McDonagh classified IL21 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease IL21 Ellen McDonagh commented on IL21
Infantile enterocolitis & monogenic inflammatory bowel disease IL10 Ellen McDonagh classified IL10 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease G6PC3 Ellen McDonagh classified G6PC3 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease G6PC3 Ellen McDonagh commented on G6PC3
Infantile enterocolitis & monogenic inflammatory bowel disease FERMT1 Ellen McDonagh classified FERMT1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease FERMT1 Ellen McDonagh classified FERMT1 as red
Infantile enterocolitis & monogenic inflammatory bowel disease FERMT1 Ellen McDonagh commented on FERMT1
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Ellen McDonagh marked EPCAM as ready
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Ellen McDonagh commented on EPCAM
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Ellen McDonagh classified EPCAM as green
Infantile enterocolitis & monogenic inflammatory bowel disease DKC1 Ellen McDonagh classified DKC1 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease DKC1 Ellen McDonagh commented on DKC1
Infantile enterocolitis & monogenic inflammatory bowel disease CTLA4 Ellen McDonagh classified CTLA4 as green
Infantile enterocolitis & monogenic inflammatory bowel disease CTLA4 Ellen McDonagh classified CTLA4 as red
Infantile enterocolitis & monogenic inflammatory bowel disease CTLA4 Ellen McDonagh commented on CTLA4
Infantile enterocolitis & monogenic inflammatory bowel disease COL7A1 Ellen McDonagh classified COL7A1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease COL7A1 Ellen McDonagh commented on COL7A1
Infantile enterocolitis & monogenic inflammatory bowel disease PLCG2 Ellen McDonagh classified PLCG2 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease PLCG2 Ellen McDonagh commented on PLCG2
Infantile enterocolitis & monogenic inflammatory bowel disease NCF1 Ellen McDonagh marked NCF1 as ready
Infantile enterocolitis & monogenic inflammatory bowel disease NCF1 Ellen McDonagh classified NCF1 as green
Infantile enterocolitis & monogenic inflammatory bowel disease NCF1 Ellen McDonagh commented on NCF1
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Ellen McDonagh classified IKBKG as green
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Ellen McDonagh commented on IKBKG
Infantile enterocolitis & monogenic inflammatory bowel disease GUCY2C Ellen McDonagh classified GUCY2C as green
Infantile enterocolitis & monogenic inflammatory bowel disease GUCY2C Ellen McDonagh commented on GUCY2C
Infantile enterocolitis & monogenic inflammatory bowel disease ADAM17 Ellen McDonagh classified ADAM17 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease ADAM17 Ellen McDonagh commented on ADAM17
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Ellen McDonagh classified ZAP70 as amber
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Ellen McDonagh classified ZAP70 as green
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Ellen McDonagh commented on ZAP70
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR2 Neil shah reviewed TGFBR2
Infantile enterocolitis & monogenic inflammatory bowel disease TGFBR1 Neil shah reviewed TGFBR1
Infantile enterocolitis & monogenic inflammatory bowel disease STAT3 Neil shah reviewed STAT3
Infantile enterocolitis & monogenic inflammatory bowel disease STAT1 Neil shah reviewed STAT1
Infantile enterocolitis & monogenic inflammatory bowel disease RTEL1 Neil shah reviewed RTEL1
Infantile enterocolitis & monogenic inflammatory bowel disease RIPK2 Neil shah reviewed RIPK2
Infantile enterocolitis & monogenic inflammatory bowel disease RAG1 Neil shah reviewed RAG1
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3R1 Neil shah reviewed PIK3R1
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Neil shah reviewed PIK3CD
Infantile enterocolitis & monogenic inflammatory bowel disease NPC1 Neil shah reviewed NPC1
Infantile enterocolitis & monogenic inflammatory bowel disease MASP2 Neil shah reviewed MASP2
Infantile enterocolitis & monogenic inflammatory bowel disease IL21 Neil shah reviewed IL21
Infantile enterocolitis & monogenic inflammatory bowel disease IL10 Neil shah reviewed IL10
Infantile enterocolitis & monogenic inflammatory bowel disease G6PC3 Neil shah reviewed G6PC3
Infantile enterocolitis & monogenic inflammatory bowel disease FERMT1 Neil shah reviewed FERMT1
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Neil shah reviewed EPCAM
Infantile enterocolitis & monogenic inflammatory bowel disease DKC1 Neil shah reviewed DKC1
Infantile enterocolitis & monogenic inflammatory bowel disease CTLA4 Neil shah reviewed CTLA4
Infantile enterocolitis & monogenic inflammatory bowel disease COL7A1 Neil shah reviewed COL7A1
Infantile enterocolitis & monogenic inflammatory bowel disease PLCG2 Neil shah reviewed PLCG2
Infantile enterocolitis & monogenic inflammatory bowel disease NCF1 Neil shah reviewed NCF1
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Neil shah reviewed IKBKG
Infantile enterocolitis & monogenic inflammatory bowel disease GUCY2C Neil shah reviewed GUCY2C
Infantile enterocolitis & monogenic inflammatory bowel disease ADAM17 Neil shah reviewed ADAM17
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Neil shah reviewed ZAP70
Infantile enterocolitis & monogenic inflammatory bowel disease XIAP Neil shah reviewed XIAP
Infantile enterocolitis & monogenic inflammatory bowel disease WAS Neil shah reviewed WAS
Infantile enterocolitis & monogenic inflammatory bowel disease TTC7A Neil shah reviewed TTC7A
Infantile enterocolitis & monogenic inflammatory bowel disease TTC37 Neil shah reviewed TTC37
Infantile enterocolitis & monogenic inflammatory bowel disease STXBP2 Neil shah reviewed STXBP2
Infantile enterocolitis & monogenic inflammatory bowel disease SLC37A4 Neil shah reviewed SLC37A4
Infantile enterocolitis & monogenic inflammatory bowel disease SKIV2L Neil shah reviewed SKIV2L
Infantile enterocolitis & monogenic inflammatory bowel disease SH2D1A Neil shah reviewed SH2D1A
Infantile enterocolitis & monogenic inflammatory bowel disease RAG2 Neil shah reviewed RAG2
Infantile enterocolitis & monogenic inflammatory bowel disease PTEN Neil shah reviewed PTEN
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Neil shah reviewed NCF4
Infantile enterocolitis & monogenic inflammatory bowel disease NCF2 Neil shah reviewed NCF2
Infantile enterocolitis & monogenic inflammatory bowel disease MVK Neil shah reviewed MVK
Infantile enterocolitis & monogenic inflammatory bowel disease MEFV Neil shah reviewed MEFV
Infantile enterocolitis & monogenic inflammatory bowel disease LRBA Neil shah reviewed LRBA
Infantile enterocolitis & monogenic inflammatory bowel disease LIG4 Neil shah reviewed LIG4
Infantile enterocolitis & monogenic inflammatory bowel disease ITGB2 Neil shah reviewed ITGB2
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RG Neil shah reviewed IL2RG
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RA Neil shah reviewed IL2RA
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RB Neil shah reviewed IL10RB
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RA Neil shah reviewed IL10RA
Infantile enterocolitis & monogenic inflammatory bowel disease ICOS Neil shah reviewed ICOS
Infantile enterocolitis & monogenic inflammatory bowel disease HPS6 Neil shah reviewed HPS6
Infantile enterocolitis & monogenic inflammatory bowel disease HPS4 Neil shah reviewed HPS4
Infantile enterocolitis & monogenic inflammatory bowel disease HPS1 Neil shah reviewed HPS1
Infantile enterocolitis & monogenic inflammatory bowel disease FOXP3 Neil shah reviewed FOXP3
Infantile enterocolitis & monogenic inflammatory bowel disease DOCK8 Neil shah reviewed DOCK8
Infantile enterocolitis & monogenic inflammatory bowel disease DCLRE1C Neil shah reviewed DCLRE1C
Infantile enterocolitis & monogenic inflammatory bowel disease CYBB Neil shah reviewed CYBB
Infantile enterocolitis & monogenic inflammatory bowel disease CYBA Neil shah reviewed CYBA
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Neil shah reviewed CD40LG
Infantile enterocolitis & monogenic inflammatory bowel disease CD3G Neil shah reviewed CD3G
Infantile enterocolitis & monogenic inflammatory bowel disease BTK Neil shah reviewed BTK
Infantile enterocolitis & monogenic inflammatory bowel disease AICDA Neil shah reviewed AICDA
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Neil shah reviewed ADA
Infantile enterocolitis & monogenic inflammatory bowel disease CYBA Ellen McDonagh marked CYBA as ready
Infantile enterocolitis & monogenic inflammatory bowel disease CYBA Ellen McDonagh classified CYBA as green
Infantile enterocolitis & monogenic inflammatory bowel disease CYBA Ellen McDonagh commented on CYBA
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Ellen McDonagh marked CD40LG as ready
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Ellen McDonagh classified CD40LG as green
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Ellen McDonagh commented on CD40LG
Infantile enterocolitis & monogenic inflammatory bowel disease CD3G Ellen McDonagh marked CD3G as ready
Infantile enterocolitis & monogenic inflammatory bowel disease CD3G Ellen McDonagh classified CD3G as green
Infantile enterocolitis & monogenic inflammatory bowel disease CD3G Ellen McDonagh commented on CD3G
Infantile enterocolitis & monogenic inflammatory bowel disease BTK Ellen McDonagh marked BTK as ready
Infantile enterocolitis & monogenic inflammatory bowel disease BTK Ellen McDonagh classified BTK as green
Infantile enterocolitis & monogenic inflammatory bowel disease BTK Ellen McDonagh commented on BTK
Infantile enterocolitis & monogenic inflammatory bowel disease AICDA Ellen McDonagh marked AICDA as ready
Infantile enterocolitis & monogenic inflammatory bowel disease AICDA Ellen McDonagh classified AICDA as green
Infantile enterocolitis & monogenic inflammatory bowel disease AICDA Ellen McDonagh commented on AICDA
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Ellen McDonagh marked ADA as ready
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Ellen McDonagh classified ADA as green
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Ellen McDonagh commented on ADA
Infantile enterocolitis & monogenic inflammatory bowel disease TTC37 Sarah Leigh edited their review of TTC37
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RA Sarah Leigh edited their review of IL10RA
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Sarah Leigh edited their review of ZAP70
Infantile enterocolitis & monogenic inflammatory bowel disease ZAP70 Sarah Leigh commented on ZAP70
Infantile enterocolitis & monogenic inflammatory bowel disease RAG2 Sarah Leigh reviewed RAG2
Infantile enterocolitis & monogenic inflammatory bowel disease PLCG2 Sarah Leigh reviewed PLCG2
Infantile enterocolitis & monogenic inflammatory bowel disease NCF1 Sarah Leigh reviewed NCF1
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Sarah Leigh edited their review of PIK3CD
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3CD Sarah Leigh commented on PIK3CD
Infantile enterocolitis & monogenic inflammatory bowel disease PIK3R1 Sarah Leigh reviewed PIK3R1
Infantile enterocolitis & monogenic inflammatory bowel disease LIG4 Sarah Leigh edited their review of LIG4
Infantile enterocolitis & monogenic inflammatory bowel disease LIG4 Sarah Leigh commented on LIG4
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RG Sarah Leigh edited their review of IL2RG
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RG Sarah Leigh commented on IL2RG
Infantile enterocolitis & monogenic inflammatory bowel disease ITGB2 Sarah Leigh reviewed ITGB2
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Sarah Leigh edited their review of IKBKG
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Sarah Leigh edited their review of IKBKG
Infantile enterocolitis & monogenic inflammatory bowel disease IKBKG Sarah Leigh commented on IKBKG
Infantile enterocolitis & monogenic inflammatory bowel disease GUCY2C Sarah Leigh edited their review of GUCY2C
Infantile enterocolitis & monogenic inflammatory bowel disease GUCY2C Sarah Leigh commented on GUCY2C
Infantile enterocolitis & monogenic inflammatory bowel disease DOCK8 Sarah Leigh commented on DOCK8
Infantile enterocolitis & monogenic inflammatory bowel disease CD3G Sarah Leigh reviewed CD3G
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Sarah Leigh edited their review of ADA
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Sarah Leigh edited their review of ADA
Infantile enterocolitis & monogenic inflammatory bowel disease ADA Sarah Leigh commented on ADA
Infantile enterocolitis & monogenic inflammatory bowel disease ADAM17 Sarah Leigh reviewed ADAM17
Infantile enterocolitis & monogenic inflammatory bowel disease XIAP Sarah Leigh reviewed XIAP
Infantile enterocolitis & monogenic inflammatory bowel disease WAS Sarah Leigh edited their review of WAS
Infantile enterocolitis & monogenic inflammatory bowel disease WAS Sarah Leigh commented on WAS
Infantile enterocolitis & monogenic inflammatory bowel disease STXBP2 Sarah Leigh reviewed STXBP2
Infantile enterocolitis & monogenic inflammatory bowel disease SLC37A4 Sarah Leigh edited their review of SLC37A4
Infantile enterocolitis & monogenic inflammatory bowel disease SLC37A4 Sarah Leigh commented on SLC37A4
Infantile enterocolitis & monogenic inflammatory bowel disease SH2D1A Sarah Leigh commented on SH2D1A
Infantile enterocolitis & monogenic inflammatory bowel disease PTEN Sarah Leigh edited their review of PTEN
Infantile enterocolitis & monogenic inflammatory bowel disease PTEN Sarah Leigh commented on PTEN
Infantile enterocolitis & monogenic inflammatory bowel disease NCF4 Sarah Leigh commented on NCF4
Infantile enterocolitis & monogenic inflammatory bowel disease NCF2 Sarah Leigh commented on NCF2
Infantile enterocolitis & monogenic inflammatory bowel disease MVK Sarah Leigh reviewed MVK
Infantile enterocolitis & monogenic inflammatory bowel disease MEFV Sarah Leigh commented on MEFV
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RA Sarah Leigh edited their review of IL2RA
Infantile enterocolitis & monogenic inflammatory bowel disease IL2RA Sarah Leigh commented on IL2RA
Infantile enterocolitis & monogenic inflammatory bowel disease ICOS Sarah Leigh commented on ICOS
Infantile enterocolitis & monogenic inflammatory bowel disease HPS6 Sarah Leigh commented on HPS6
Infantile enterocolitis & monogenic inflammatory bowel disease HPS6 Sarah Leigh reviewed HPS6
Infantile enterocolitis & monogenic inflammatory bowel disease HPS4 Sarah Leigh commented on HPS4
Infantile enterocolitis & monogenic inflammatory bowel disease HPS1 Sarah Leigh commented on HPS1
Infantile enterocolitis & monogenic inflammatory bowel disease DCLRE1C Sarah Leigh commented on DCLRE1C
Infantile enterocolitis & monogenic inflammatory bowel disease CYBB Sarah Leigh edited their review of CYBB
Infantile enterocolitis & monogenic inflammatory bowel disease CYBB Sarah Leigh commented on CYBB
Infantile enterocolitis & monogenic inflammatory bowel disease CYBA Sarah Leigh commented on CYBA
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Sarah Leigh commented on CD40LG
Infantile enterocolitis & monogenic inflammatory bowel disease CD40LG Sarah Leigh commented on CD40LG
Infantile enterocolitis & monogenic inflammatory bowel disease BTK Sarah Leigh commented on BTK
Infantile enterocolitis & monogenic inflammatory bowel disease AICDA Sarah Leigh commented on AICDA
Infantile enterocolitis & monogenic inflammatory bowel disease TTC37 Sarah Leigh reviewed TTC37
Infantile enterocolitis & monogenic inflammatory bowel disease SKIV2L Sarah Leigh edited their review of SKIV2L
Infantile enterocolitis & monogenic inflammatory bowel disease SKIV2L Sarah Leigh reviewed SKIV2L
Infantile enterocolitis & monogenic inflammatory bowel disease LRBA Sarah Leigh reviewed LRBA
Infantile enterocolitis & monogenic inflammatory bowel disease FOXP3 Sarah Leigh reviewed FOXP3
Infantile enterocolitis & monogenic inflammatory bowel disease IL10 Sarah Leigh commented on IL10
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RB Sarah Leigh classified IL10RB as green
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RB Sarah Leigh commented on IL10RB
Infantile enterocolitis & monogenic inflammatory bowel disease TTC7A Sarah Leigh classified TTC7A as green
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RA Sarah Leigh classified IL10RA as green
Infantile enterocolitis & monogenic inflammatory bowel disease IL10RA Sarah Leigh reviewed IL10RA
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Sarah Leigh added EPCAM to panel
Infantile enterocolitis & monogenic inflammatory bowel disease EPCAM Sarah Leigh reviewed EPCAM
Infantile enterocolitis & monogenic inflammatory bowel disease TTC7A Sarah Leigh edited their review of TTC7A
Infantile enterocolitis & monogenic inflammatory bowel disease TTC7A Sarah Leigh commented on TTC7A