IL10

interleukin 10
OMIM: 124092, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels

Amber IL10 in Infantile enterocolitis & monogenic inflammatory bowel disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.19

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • UKGTN
  • Eligibility statement prior genetic testing
  • Expert list
Phenotypes
  • IL-10 signalling defects / deficiency
  • IL10-Related Inflammatory Bowel Disease

Red IL10 in Familial Meniere Disease

Level 3: Other hearing and ear disorders
Level 2: Hearing and ear disorders
Version 1.1

review Not set
Sources
  • Literature

Green IL10 in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.59

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • UKGTN
Phenotypes
  • Inflammatory Bowel Disease (Very Early Onset)
  • Crohn disease

Green IL10 in COVID-19 research


Level 2: Viral research
Version 1.76

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • GOSH PID v.8.0
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
Phenotypes
  • Early-onset inflammatory bowel disease
  • Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome
  • Inflammatory bowel disease (IBD) Folliculitis, recurrent respiratory diseases, arthritis,
  • Diseases of Immune Dysregulation

No list IL10 in Sudden death in young people

Level 3: Cardiac arrhythmia
Level 2: Cardiovascular disorders
Version 1.15

review Unknown
Sources
  • Expert Review Removed
  • Literature
Tags
  • promoter
  • curated_removed

Green IL10 in Primary immunodeficiency


Version 2.402
Latest signed off version: v2.1 (24 Feb 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
Phenotypes
  • Early-onset inflammatory bowel disease
  • Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome
  • Inflammatory bowel disease (IBD) Folliculitis, recurrent respiratory diseases, arthritis,
  • Diseases of Immune Dysregulation

Red IL10 in Severe Paediatric Disorders


Version 1.66

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Red
  • Expert list
Phenotypes
  • {Glioma, susceptibility to, somatic}, 137800

Green IL10 in NewbornFullV1


Version 0.1

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green