TNNI3

troponin I3, cardiac type
OMIM: 191044, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels

Red TNNI3 in Left Ventricular Noncompaction Cardiomyopathy

Level 3: Cardiomyopathy
Level 2: Cardiovascular disorders
Version 1.4

review Not set
Sources
  • Expert Review Red
  • Eligibility statement prior genetic testing
Phenotypes
  • Hypertrophic cardiomyopathy

Green TNNI3 in Hypertrophic cardiomyopathy - teen and adult

Level 3: Cardiomyopathy
Level 2: Cardiovascular disorders
Version 2.19
Latest signed off version: v2.18 (16 Dec 2021)

Component of the following Super Panels:

  • Sudden cardiac death
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • South West GLH
    • London South GLH
    • North West GLH
    • Expert Review Green
    • Eligibility statement prior genetic testing
    • Expert list
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    • UKGTN
    Phenotypes
    • Cardiomyopathy, familial hypertrophic, 7
    • ?Cardiomyopathy, dilated, 2A (611880)
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, hypertrophic, 7 (613690)

    Green TNNI3 in Dilated Cardiomyopathy and conduction defects

    Level 3: Cardiomyopathy
    Level 2: Cardiovascular disorders
    Version 1.67

    review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • South West GLH
    • London South GLH
    • North West GLH
    • Expert Review Green
    • UKGTN
    • Expert list
    • Emory Genetics Laboratory
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, dilated, 2A,
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, hypertrophic, 7 (613690)
    • ?Cardiomyopathy, dilated, 2A (611880)

    Green TNNI3 in Dilated cardiomyopathy - adult and teen

    Level 3: Cardiomyopathy
    Level 2: Cardiovascular disorders
    Version 1.13
    Latest signed off version: v1.6 (15 Oct 2020)

    Component of the following Super Panels:

  • Sudden cardiac death
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • UKGTN
    • South West GLH
    • Radboud University Medical Center, Nijmegen
    • Illumina TruGenome Clinical Sequencing Services
    • London South GLH
    • North West GLH
    • Expert list
    • Emory Genetics Laboratory
    • South West GLH
    • London South GLH
    • North West GLH
    Phenotypes
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, dilated, 2A,
    • ?Cardiomyopathy, dilated, 2A (611880)
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, hypertrophic, 7 (613690)

    Red TNNI3 in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.394

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    Phenotypes
    • Cardiomyopathy

    Green TNNI3 in Cardiomyopathies - including childhood onset


    Version 1.19
    Latest signed off version: v1.4 (19 Feb 2020)

    review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • South West GLH
    • London South GLH
    • Expert Review Green
    Phenotypes
    • Hypertrophic cardiomyopathy
    • Cardiomyopathy, familial hypertrophic, 7
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, dilated, 2A,

    Red TNNI3 in Hereditary neuropathy NOT PMP22 copy number


    Version 1.28
    Latest signed off version: v1.27 (16 Dec 2021)

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    • NHS GMS
    • South West GLH
    Phenotypes
    • Cardiomyopathy